• Osteoarthritis

    • What does it mean to have osteoarthritis (OA) in my knee?

      OA is a chronic (ongoing) long-term disease. Its symptoms can include sore or stiff knees, limited range of knee movement, cracking sensations with knee movement, swelling of the knees, and knee pain. If you’re suffering from OA symptoms, you’re not alone. OA affects more than 30 million Americans.2

    • How do I know if I have OA?

      Your physician will be able to tell based on his or her observations and your medical history. An X-ray or MRI may help your doctor see any problems with your knee(s).3

    • Are there other non-surgical treatments available for OA?

      Yes, there are other non‐surgical treatments available. They include, but are not limited to:

      Non‐drug treatments

      • Avoiding activities that cause pain in your knee
      • Exercise
      • Physical therapy
      • Weight loss (if you are overweight)
      • Removal of excess fluid from the knee


      Drug therapy

      • Pain medications such as acetaminophen or stronger prescription medications
      • Drugs that reduce swelling, such as aspirin, and other nonsteroidal anti‐inflammatory drugs (NSAIDs), such as ibuprofen and naproxen
      • Corticosteroids that are injected directly into the joint

      Talk to your healthcare professional about non‐surgical treatment options that may be right for you.1

  • When Making Your
    Treatment Decision

    • Could 1% sodium hyaluronate help me?

      1% sodium hyaluronate has been studied for the treatment of OA knee pain in patients who don’t get enough relief from simple pain medications, such as acetaminophen, or from exercise and physical therapy. Through a series of 3 injections administered by your healthcare provider, 1% sodium hyaluronate may provide pain relief for up to 6 months and may reduce your need for rescue medications such as acetaminophen. Talk with your healthcare professional if this treatment may be right for you!1

    • Are there any reasons why I shouldn’t be treated with 1% sodium hyaluronate?

      Your doctor will determine if you are an appropriate candidate for 1% sodium hyaluronate.

      Do not take 1% sodium hyaluronate if you have had previous allergic reactions to 1% sodium hyaluronate or hyaluronan products.

      1% sodium hyaluronate should not be injected into the knee if you have a knee joint infection or skin diseases or infections around the injection site.1

    • Should I get 1% sodium hyaluronate if I’m pregnant?

      1% sodium hyaluronate has not been tested in pregnant women or women who are nursing. Tell your doctor if you think you are pregnant or nursing a child before treatment with 1% sodium hyaluronate.1

    • Can people under 21 get 1% sodium hyaluronate?

      1% sodium hyaluronate has not been tested in people less than 21 years of age.1

  • About the Treatment

    • Where do I get my treatment?

      Your doctor may have 1% sodium hyaluronate already available at his or her office. If not, you can fill your prescription for 1% sodium hyaluronate at the pharmacy to bring to your doctor’s appointment.

    • What can I expect during the treatment?

      Your doctor will inject 1% sodium hyaluronate into your knee joint using the prefilled syringe. The entire injection will be given over the course of 2 to 3 minutes.1

    • Will the injection hurt?

      Anesthesia of the site is not required for the injection, but a local anesthetic may be used at your doctor's discretion.1

    • Can I give myself 1% sodium hyaluronate injections at home?

      No. 1% sodium hyaluronate injections must be administered by a healthcare professional within a professional care setting. 1

    • Will I receive more than 1 injection?

      1% sodium hyaluronate is given as 3 injections over 3 office visits with your physician. It’s important to get all 3 injections, as this provided the most significant pain reduction in clinical studies.1

  • After the treatment

    • What can I expect after the treatment?

      After you receive an injection of 1% sodium hyaluronate, you may experience temporary pain or swelling of the injected joint.1

    • Will I be able to drive myself home from the treatment?

      After receiving your injection, limit physical activity. Someone may need to drive you home from the doctor’s office.1

    • What precautions should I take after receiving a 1% sodium hyaluronate injection?

      Avoid strenuous physical activity for 48 hours following the injection to help keep your knee from swelling. Some examples of activities to avoid include:

      • Running
      • Tennis
      • Hiking
      • Jumping
      • Swimming
      • Heavy lifting (weight lifting)
      • Jogging
      • Bicycling
      • Aerobic exercise

      Do not stand on your feet for more than 1 hour at a time during the first 48 hours following your injection.

      You should ask your doctor when to begin physical activity again.1

    • When should I call my doctor if I’m experiencing side effects?

      You should call your doctor immediately if you experience any side effects or symptoms after receiving the 1% sodium hyaluronate injection.1

    • How long will treatment relieve my pain?

      A 3-injection regimen of 1% sodium hyaluronate may provide pain relief for up to 6 months.1

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WHAT IS 1% SODIUM HYALURONATE USED FOR?

1% sodium hyaluronate is used to help relieve knee pain due to osteoarthritis. It is used for patients who do not get enough relief from simple pain medications, such as acetaminophen, or from exercise and physical therapy.

Osteoarthritis is a condition that involves the wearing down of cartilage (the protective covering on the ends of your bones). In osteoarthritis, there may not be enough, or there may be a decrease in the quality, of the gel‐like substance in the joint and surrounding tissues for the joint to work properly.

IMPORTANT SAFETY INFORMATION

Are there any reasons why I should not take 1% sodium hyaluronate?

  • Your doctor will determine if you are an appropriate candidate for 1% sodium hyaluronate.
  • Do not take 1% sodium hyaluronate if you have had previous allergic reactions to 1% sodium hyaluronate or hyaluronan products.
  • 1% sodium hyaluronate should not be injected into the knee if you have a knee joint infection or skin diseases or infections around the injection site.

What should my doctor warn me about?

  • After you receive an injection of 1% sodium hyaluronate, you may experience temporary pain or swelling of the injected joint.
  • 1% sodium hyaluronate has not been tested in pregnant women or women who are nursing. Tell your doctor if you think you are pregnant or nursing a child before agreeing to be injected with 1% sodium hyaluronate.
  • 1% sodium hyaluronate has not been tested in persons less than 21 years of age.

What are some of the possible side effects of 1% sodium hyaluronate?

The following are the most common adverse events that occurred during the clinical trial of 1% sodium hyaluronate:

  • Pain in the knee or at the injection site
  • Swelling and discomfort of the joint

What should I do after receiving a 1% sodium hyaluronate injection?

  • After receiving your injection, limit physical activity. Someone may need to drive you home from the doctor’s office.
  • Avoid strenuous physical activity for 48 hours following the injection to help keep your knee from swelling. Some examples of activities to avoid include: running, tennis, hiking, jumping, swimming, heavy lifting (weight lifting), jogging, bicycling, and aerobic exercise.
  • Do not stand on your feet for more than one hour at a time during the first 48 hours following your injection.
  • You should ask your doctor when you should begin major physical activities again.

When should I call my doctor?

If you experience any of the adverse effects or symptoms described earlier or if you have any other problems, you should call your doctor immediately.

Please read the Patient Information and Directions for Use in the full Prescribing Information.

REFERENCES

1.

1% Sodium Hyaluronate [Prescribing Information]. North Wales, PA: Teva Pharmaceuticals, Inc; 2019.


2.

Centers for Disease Control. Osteoarthritis. https://www.cdc.gov/arthritis/basics/osteoarthritis.htm. Accessed May 23, 2019.


3.

Arthritis Foundation. Osteoarthritis Diagnosis. https://www.arthritis.org/about-arthritis/types/osteoarthritis/diagnosing.php. Accessed March 18, 2019.