1% sodium hyaluronate is a gel‐like, elastic, sterile product containing highly purified hyaluronan (pronounced hye‐a‐loo‐ROE‐nan). Hyaluronan is a natural substance found in the body. It is present in particularly high amounts in joint tissues and in the fluid that fills the joints. The body’s own hyaluronan acts like a lubricant and a shock absorber in the joint. It is needed for the joint to function properly.¹

1% sodium hyaluronate is used to help relieve knee pain due to osteoarthritis (OA), with a series of 3 injections given by your healthcare provider. It is used for patients who do not get enough relief from simple pain medications, such as acetaminophen, or from exercise and physical therapy.

OA is a condition that involves the wearing down of cartilage (the protective covering on the ends of your bones). In OA, there may not be enough, or there may be a decrease in the quality, of the gel‐like substance in the joint and surrounding tissues for the joint to work properly.¹

1% sodium hyaluronate is given as 3 injections over 3 weekly visits with your physician. It’s important to get all 3 injections as this provided the most significant pain reduction in clinical studies.

1% sodium hyaluronate comes in prefilled syringes containing 2 mL (about half a teaspoon) of product. It is given by injection directly into the knee joint by a doctor or other qualified healthcare professional in his or her office once a week for 3 weeks, for a total of 3 injections.¹

• Your doctor will determine if you are an appropriate candidate for 1% sodium hyaluronate.
• Do not take 1% sodium hyaluronate if you have had previous allergic reactions to 1% sodium hyaluronate or hyaluronan products.
• 1% sodium hyaluronate should not be injected into the knee if you have a knee joint infection or skin diseases or infections around the injection site.¹

• After you receive an injection of 1% sodium hyaluronate, you may experience temporary pain or swelling of the injected joint.
• 1% sodium hyaluronate has not been tested in pregnant women or women who are nursing. Tell your doctor if you think you are pregnant or nursing a child before treatment with 1% sodium hyaluronate.
• 1% sodium hyaluronate has not been tested in people less than 21 years of age.¹

The following are the most common adverse events that occurred during the clinical trial of 1% sodium hyaluronate:

• Pain in the knee or at the injection site
• Swelling and discomfort of the joint¹

Based on the results from a clinical study, subjects with knee pain due to OA experienced relief of this pain as well as improvement in knee function lasting up to 6 months after receiving 1% sodium hyaluronate.¹