PERSONALIZED DOSING FOR
HD CHOREA¹

With personalized dosing from AUSTEDO XR®, your doctor can find the proper dose to help you reduce HD chorea movements.¹

Your healthcare provider will start you at a low dose and gradually increase your dose over time. This approach allows your body to get used to the medication and can help with side effects as HD chorea movements are reduced. This way, your doctor can find a dose that works for you. This process is called titration.^1,2

Talk to your doctor, nurse
practitioner, or other healthcare provider about AUSTEDO XR.

See how Teva Shared Solutions® can help
make treatment affordable

one pill

once-daily

extended-release

Not actual image of the free Titration Kit.

Start at no cost with 2

convenient options.

Your doctor may provide you a FREE Titration Kit to either:

Take home
from their
office

Pick up
at your
pharmacy*

The Titration Kit will guide you through your first month with AUSTEDO XR.

After that, enroll in Teva Shared Solutions® patient support to continue to get
your prescription at the lowest cost possible.

*With free trial voucher at AUSTEDOcardform.com

The AUSTEDO XR Titration Kit gradually increases your medication to find the proper dose to help reduce your HD chorea movements¹

This is the dosing schedule for the Titration Kit. Upon completion of the kit, your doctor will write you a prescription for AUSTEDO XR and determine what daily dose is right for you.

Titration Schedule

Once-Daily Dosing (mg)

Dosing Totals

Week 1

12 mg

Week 2

18 mg

Week 3

24 mg

Week 4

30 mg

Titration
Schedule

Once-Daily
Dosing (mg)

Dosing
Totals

Week 1

12 mg

Week 2

18 mg

Week 3

24 mg

Week 4

30 mg

Pills are for illustration only and not actual size or likeness.

Your HD chorea treatment needs are unique to you

AUSTEDO XR has different dosing strengths
so your healthcare provider can find the dose
that works for you.¹

Starting dose

Your doctor will start you on a low dose of AUSTEDO XR and work with you to find your maintenance dose.

Maintenance dose

Once you reach a dose that provides effective HD chorea movement reduction and is tolerated, that will become your maintenance dose. If you want to increase your dose, you and your doctor can discuss more dosing options.

Why AUSTEDO XR offers personalized dosing

This titration approach could mean fewer side effects and more time to understand how the medication affects your body. It also means you and your doctor work together to figure out the dose that's effective for you.

Take AUSTEDO XR/
AUSTEDO as prescribed by your doctor¹

AUSTEDO XR should be taken:

Once daily

With water

Whole (do not
crush or break)

With or without food

AUSTEDO should be taken:

Twice daily

With water

Whole (do not
crush or break)

With food

If you cannot swallow AUSTEDO XR/AUSTEDO tablets whole, tell your healthcare provider. You may need a different medication.

Before starting AUSTEDO XR, talk to your doctor about what to do if you miss a dose
Add your dosing schedule to your other daily routines so you will be less likely to miss a dose
Tell your doctor if you stop taking AUSTEDO XR for more than 1 week. Do not take another dose until you talk to your doctor¹

Follow the dosing schedule exactly as prescribed by your healthcare provider¹
Set an alarm as a treatment reminder
Keep your AUSTEDO XR tablets in the same place so you know where they are

Use the HD Chorea Treatment Tracking Guide for AUSTEDO XR to help set treatment goals, record when you take AUSTEDO XR, and note any questions you may have for your doctor.

Get the guide

For additional information about how to take AUSTEDO XR, please read the Medication Guide. Ask your doctor if you have any questions about taking AUSTEDO XR.

Track your progress

Download the HD Chorea Treatment Tracking Guide to record
when AUSTEDO XR is taken and note any questions for your doctor.

Get the tracker

AUSTEDO XR^® (deutetrabenazine) extended-release tablets and AUSTEDO^® (deutetrabenazine) tablets are prescription medicines that are used to treat:

the involuntary movements (chorea) of Huntington’s disease. AUSTEDO XR and AUSTEDO do not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.
movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO XR and AUSTEDO are safe and effective in children.

AUSTEDO XR^® and AUSTEDO^® can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR or AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR or AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO XR or AUSTEDO if you:

have Huntington’s disease and are depressed or have thoughts of suicide.
have liver problems.
are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR or AUSTEDO. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO XR or AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR or AUSTEDO.
are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR or AUSTEDO. Do not start AUSTEDO XR or AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
are taking tetrabenazine. If your healthcare provider plans to switch you from tetrabenazine to AUSTEDO XR or AUSTEDO, take your first dose of AUSTEDO XR or AUSTEDO on the day after your last dose of tetrabenazine.
are taking valbenazine.

Other possible serious side effects include:

Irregular heartbeat (QT prolongation). AUSTEDO XR and AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR or AUSTEDO with certain medicines may increase this chance.
Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO XR and AUSTEDO. While taking AUSTEDO XR or AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR or AUSTEDO affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR or AUSTEDO may increase any sleepiness caused by AUSTEDO XR and AUSTEDO.

The most common side effects of AUSTEDO in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with Huntington’s disease or tardive dyskinesia.

These are not all the possible side effects of AUSTEDO XR or AUSTEDO. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the accompanying Medication Guide.

References:

1. AUSTEDO XR® (deutetrabenazine) extended-release tablets/AUSTEDO® (deutetrabenazine) tablets current Prescribing Information. Parsippany, NJ: Teva Neuroscience, Inc.

2. Taylor D. What does 'titration' mean? Cleveland Clinic. November 13, 2019. Accessed March 14, 2024. https://health.clevelandclinic.org/what-does-titration-mean

PERSONALIZED DOSING FOR HD CHOREA1

Talk to your doctor, nurse practitioner, or other healthcare provider about AUSTEDO XR.

Start at no cost with 2 convenient options.

The AUSTEDO XR Titration Kit gradually increases your medication to find the proper dose to help reduce your HD chorea movements1

Your HD chorea treatment needs are unique to you

Take AUSTEDO XR/AUSTEDO as prescribed by your doctor1

AUSTEDO XR should be taken:

AUSTEDO should be taken:

Treatment tips

Have a plan

Set a routine

Record your treatment