Go about
your day
with reduced involuntary movements¹

Once-daily AUSTEDO XR (deutetrabenazine) extended-release tablets contains the same active ingredient
as twice-daily AUSTEDO (deutetrabenazine) tablets. Data on this page is based on twice-daily dosing. ¹

In a 12-week clinical study,

AUSTEDO significantly
reduced HD chorea¹

People taking AUSTEDO saw more than
2x reduction in HD chorea vs placebo.*

With Austedo® there was more than twice the reduction in involuntary body movements at 12 weeks compared with placebo.

*4.4-point improvement in people taking AUSTEDO vs 1.9 in people taking placebo based on Total Maximal Chorea (TMC) score. The TMC score is used to measure HD chorea movements in the face, mouth, trunk, both arms, and both legs.^1,2

established safety results

~3 years³

This was an open-label study, which is a drug trial in which all participants are aware of the drug being tested.⁴

51 percent of HD patients on Austedo saw treatment success. 42 percent of doctors saw treatment success.

People reported improvement in HD chorea symptoms^1,2

Both doctors and people with HD chorea on AUSTEDO rated symptoms as “very much improved” or “much improved” at 12 weeks with AUSTEDO.

^†Treatment success is measured by perceived improvement in TMC score.

People reported improvement in their ability to perform daily activities like^2,5:

Climbing stairs
Bending, kneeling, or stooping

Lifting/carrying groceries
Walking
Dressing

Bathing
Moderate to vigorous activities

People taking AUSTEDO achieved greater improvement in the SF-36^§ Physical Functioning Score at 12 weeks vs placebo.

See study details

^§SF-36=36-Item Short Form Health Survey assessing health-related quality of life.

AUSTEDO XR/AUSTEDO does not cure the cause of the involuntary movements and it does not
treat the other symptoms of HD, such as problems with thinking or emotions.¹

When HD chorea threatened to disrupt Ray and Rhonda's retirement plans, they knew it was time to ask Ray's doctor about treatment options.

Now Playing:

Ray and Rhonda's Story

See why Ray and Rhonda made the decision to treat HD chorea.

Video Transcript:

Ray
I'm Ray. I’m 55.

Rhonda
My name is Rhonda, and I am Ray's wife.

Rhonda
Ray's dad had Huntington's disease. He wasn’t, wasn't able to walk. He ended up in a wheelchair. So that was kind of a really scary thought for me. I just assumed that our lives would be over very soon as we knew it.

Rhonda
So the first symptoms I noticed of his chorea was at night while he was sleeping, his arms would, you know, kind of start flailing and hitting and kind of it would just be like his whole body.

Ray
When I was driving to work one day, my hands started just shaking like this. It’s just weird you know, having your hands move and no, no explanation.

Rhonda
At that time. It was I was feeling a little bit desperate, like something needs to change. We can't do this anymore.

Rhonda
We made an appointment with the neurologist that week talking to her about how bad it had gotten, and she said, well, I have this drug that I would like for you to try.

Rhonda
Yeah, so his movements just became less and less as the doses increased. His sleeping now is very different. No more kicks, no more punches, no more flailing around in bed. We both noticed that small things that he would do with his hands became easier.

Ray
Yeah.

Rhonda
Buttoning his shirt, putting the leash on the dog's collar, tying his shoes. Those things became easier. So, yeah, it has far exceeded our expectations.

Rhonda
We're looking forward to taking a trip to Yellowstone. Hopefully taking our grandkids and doing some hiking. I don't know that we would have been able to continue hiking with his chorea had it continued on without the medication. I feel like that we're actually like living the way we've always wanted to live now. By going on vacations and being outdoors a lot more and having grandkids and yeah, I can't imagine life if he didn't have the medication.

Ray
It's really a deal maker for me. It just helps so much.

APPROVED USES

AUSTEDO® XR (deutetrabenazine) extended-release tablets and AUSTEDO® (deutetrabenazine) tablets are prescription medicines that are used to treat:

the involuntary movements (chorea) of Huntington’s disease. AUSTEDO XR and AUSTEDO do not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.

movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO XR and AUSTEDO are safe and effective in children.

IMPORTANT SAFETY INFORMATION

AUSTEDO XR and AUSTEDO can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR or AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR or AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Individual results may vary.

Please see the Important Safety Information at the end of this video.

Track your progress

Download the HD Chorea Treatment Tracking Guide to record when
AUSTEDO XR is taken and note any questions for your healthcare provider.

Treatment Tracking Guide

Start the conversation now

Whether you're ready to start medication or planning
ahead, talking to a healthcare provider (for example, your doctor or nurse practitioner) is an important step.

Check out the guide

AUSTEDO^® XR (deutetrabenazine) extended-release tablets and AUSTEDO^® (deutetrabenazine) tablets are prescription medicines that are used to treat:

the involuntary movements (chorea) of Huntington’s disease. AUSTEDO XR and AUSTEDO do not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington’s disease, such as problems with thinking or emotions.
movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if AUSTEDO XR and AUSTEDO are safe and effective in children.

AUSTEDO XR and AUSTEDO can cause serious side effects in people with Huntington’s disease, including: depression, suicidal thoughts, or suicidal actions. Do not start taking AUSTEDO XR or AUSTEDO if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when AUSTEDO XR or AUSTEDO is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of suicide.

Do not take AUSTEDO XR or AUSTEDO if you:

have Huntington’s disease and are depressed or have thoughts of suicide.
have liver problems.
are taking reserpine. Do not take medicines that contain reserpine with AUSTEDO XR or AUSTEDO. If your healthcare provider plans to switch you from taking reserpine to AUSTEDO XR or AUSTEDO, you must wait at least 20 days after your last dose of reserpine before you start taking AUSTEDO XR or AUSTEDO.
are taking a monoamine oxidase inhibitor (MAOI) medicine. Do not take an MAOI within 14 days after you stop taking AUSTEDO XR or AUSTEDO. Do not start AUSTEDO XR or AUSTEDO if you stopped taking an MAOI in the last 14 days. Ask your healthcare provider or pharmacist if you are not sure.
are taking tetrabenazine. If your healthcare provider plans to switch you from tetrabenazine to AUSTEDO XR or AUSTEDO, take your first dose of AUSTEDO XR or AUSTEDO on the day after your last dose of tetrabenazine.
are taking valbenazine.

Other possible serious side effects include:

Irregular heartbeat (QT prolongation). AUSTEDO XR and AUSTEDO increases your chance of having certain changes in the electrical activity in your heart. These changes can lead to a dangerous abnormal heartbeat. Taking AUSTEDO XR or AUSTEDO with certain medicines may increase this chance.
Neuroleptic Malignant Syndrome. Call your healthcare provider right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, or increased sweating.
Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
Parkinsonism. Symptoms include: slight shaking, body stiffness, trouble moving, trouble keeping your balance, or falls.

Sleepiness (sedation) is a common side effect of AUSTEDO XR and AUSTEDO. While taking AUSTEDO XR or AUSTEDO, do not drive a car or operate dangerous machinery until you know how AUSTEDO XR or AUSTEDO affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking AUSTEDO XR or AUSTEDO may increase any sleepiness caused by AUSTEDO XR and AUSTEDO.

The most common side effects of AUSTEDO in people with Huntington’s disease include sleepiness (sedation), diarrhea, tiredness, and dry mouth.

The most common side effects of AUSTEDO in people with tardive dyskinesia include inflammation of the nose and throat (nasopharyngitis) and problems sleeping (insomnia).

The most common side effects of AUSTEDO XR are expected to be similar to AUSTEDO in people with Huntington’s disease or tardive dyskinesia.

These are not all the possible side effects of AUSTEDO XR or AUSTEDO. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please read the accompanying Medication Guide.

References:

1. AUSTEDO® XR (deutetrabenazine) extended-release tablets/AUSTEDO® tablets current Prescribing Information. Parsippany, NJ: Teva Neuroscience, Inc.

2. Data on file. Parsippany, NJ: Teva Neuroscience, Inc.

3. Frank S, Testa CM, Stamler D, et al; Huntington Study Group ARC-HD Investigators. Long-term efficacy and safety of deutetrabenazine for chorea in Huntington's disease: results from the ARC-HD open-label study. Poster presented at: 27th Annual Meeting of the Huntington Study Group (HSG); October 29-31, 2020.

4. Open-label. Merriam-Webster. Updated January 1, 2024. Accessed January 24, 2024. https://www.merriam-webster.com/dictionary/open-label#medicalDictionary

5. Burgess JC, Davis B, Fogarty E, et al. Caregiver Guide for Mid to Late Stage Huntington's Disease: For Long-Term Care Facilities and In-Home Care Agencies. Huntington's Disease Society of America; 2014. Accessed January 24, 2024. http://hdsa.org/wp-content/uploads/2015/04/CaregiverGuide_Mid_Late_StageHD.pdf

Go about your day with reduced involuntary movements1

In a 12-week clinical study,

AUSTEDO significantly reduced HD chorea1

established safety results

People reported improvement in HD chorea symptoms1,2

People reported improvement in their ability to perform daily activities like2,5:

See why Ray and Rhonda made the decision to treat HD chorea